Work in Progress
Runes are very important in Wildstar, it is near 50-60% of your gear power. You want to start runeing mostly on level 50.
There are Runecrafting stations in almsot every city. If you use them, you will open Runecrafting window, there are basic runes, set runes, and equip runes tab. In basic runes tab you want only Fusion runes, as you will always want to create rune sets instead basic runes.